Endocrine Abstracts

The gut microbiota is now the subject of considerable investigation and our knowledge of its composition and understanding of functions are rapidly growing.Gut microbiota has profound impact on host physiology and it is now well-established that dysbiosis is associated with altered glycemic control and type 2 diabetes development. Targeting microbiota appears therefore as a promising strategy for the treatment of diabetic patients. Using probiotics in order to modulate blood g...

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The link between obesity and type 2 diabetes is clear on an epidemiological level, however the mechanism linking these two common disorders is not well defined. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individu...

The link between obesity and type 2 diabetes is clear on an epidemiological level, however the mechanism linking these two common disorders is not well defined. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expandability hypothesis states that a failure in the capacity for adipose tissue expansion, rather than obesity per se is the key factor linking positive energy balance and type 2 diabetes. All individu...

Laser ablation of thyroid nodules has been used for the last two decads (Pacella et al, 2000). Surprisingly, complications are less frequent in patients treated without anesthesia, probably because eventual pain is an useful alarm symptom, leading the operator to repositioning the fiber during the procedure (Pacella et al., 2015).Material and methods: A total of 32 patients were included, without using local anesthesia. Nodules were solid, 5–72 ml v...

Ethanol and laser ablation of benign thyroid nodules is bursting rapidly in clinical practice because of its efficacy, safety and economy. However, these techniques require some manual operator training. In order to facilitate this hands-on training, we propose two homemade, cheap and specific simulators to practice these clinical procedures.Material and methodsTwo models were optimized: Gel-Phantom Coruna VR16 (gelatine a...

Endocrine Connections, 2018, 7(10): 1031–1039 (DOI: https://doi.org/10.1530/EC-18-0296)...

Objectives: Assess the response of benign thyroid nodules to HIFU treatment depending on their volume and localization. Know if the treatment is painful when sedation is not used.Methods: 66 patients with benign thyroid nodules (Bethesda Category II) were treated with HIFU (Echopulse Theraclion). They were grouped in 3 categories by maximal nodule diameter as assessed by echography. Group 1: nodule diameter between 14 and 20 mm; Group 2: between 21 and 3...

Nur77 is a nuclear orphan receptor belonging to the steroid receptor superfamily. A role for Nur77 has been described in proliferation, differentiation and apoptosis, as a result of its induction in response to multiple signal transduction pathways. Previous studies have suggested that physical interaction between Nur77 and the tumor suppressor p53 can prevent p53 ubiquination and subsequent degradation by hMdm2. This suggests a possible role for Nur77 as a regulator of p53-de...